Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

The role of FOX-1 in neurodevelopment and autistic spectrum disorder  

This is a Clinical Investigator Award, providing a medical investigator with an opportunity to develop into an independent researcher. Understanding the etiology of autism is important for improving clinical treatments and diagnostic testing, as well as for understanding human neurodevelopment. The Fox-1 gene (also called A2BP1) may be involved in neurodevelopment and has also been linked to autism in a few patients. Fox-1 is a neuron-specific regulator of alternative gene splicing that appears to play a significant role in gene expression in both human and mouse brain. This research will identify genes whose alternative splicing is regulated by Fox-1 in human neuronal cells using a splicing microarray platform and identify Fox-1-dependent alternative splicing changes that occur during the differentiation of human neuronal cells to neurons. The role of these Fox-1 target genes in neurodevelopment will also be characterized in humans and mice. The studies proposed here, examining the role a brain-specific regulator of gene expression in neurodevelopment, will extend knowledge of what can cause ASD and may ultimately help to better treat, prevent, or someday even cure autism. Project Status


Funder National Institutes of Health
Fiscal Year Funding $142,677.00
Current Award Period 2009-2014
Project Number 5K08MH086297-02
Principal Investigator Fogel, Brent
Received ARRA Funding? No
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Subcategory Molecular Pathways
Strategic Plan Objective 2O. Not specific to Question 2 objectives
Federal or Private? Federal
Institution University of California, Los Angeles
State/Country California
Web Link 1 The role of FOX-1 in neurodevelopment and autistic spectrum disorder (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects The role of Fox-1 in neurodevelopment and autistic spectrum disorder | $139,471.00 | 2009 | 1K08MH086297-01A1