Project Detail
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Neuroligin regulation of central GABAergic synapses  

Synapse formation and maturation are crucial processes in the generation of neuronal circuits in the brain, and aberrant synapse development may lead to neurodevelopmental disorders such as autism. The role of neuroligins (NLs – postsynaptic cell adhesion molecules) in synapse formation may be more expansive than previously thought. This study uses biochemical methods in cultured cells to determine if a specific NL (NL2) facilitates GABAergic synapse formation and accelerates synaptic transmission by recruiting a particular type of GABAA receptor. Determining the function of neuroligins at inhibitory synapses will increase our ability to develop more effective diagnosis and treatment methods for neurodevelopmental disorders. Project Status


Funder National Institutes of Health
Fiscal Year Funding $78,000.00
Current Award Period 2009-2011
Project Number 5R03MH085224-02
Principal Investigator Fu, Zhanyan
Received ARRA Funding? Yes
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Subcategory Molecular Pathways
Strategic Plan Objective 2O. Not specific to Question 2 objectives
Federal or Private? Federal
Institution Duke University
State/Country North Carolina
Web Link 1 Neuroligin regulation of central GABAergic synapses (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects Neuroligin regulation of central GABAergic synapses | $78,000.00 | 2009 | 1R03MH085224-01