Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Function and structure adaptations in forebrain development  

A convergence of human genetic and biochemical studies in ASD and basic developmental neurobiology suggest that signaling involving the receptor tyrosine kinase MET is important for the proper assembly of forebrain circuits, with dysregulation leading to functional disruptions in both model systems and in humans. This research will investigate a risk gene (MET) for ASD by determining how alterations in gene expression impact brain development in mice. MET transcription factors and epigenetic factors will also be manipulated in cell lines to assess important regulators of the human gene. This project includes basic and clinical translational studies that will provide insight into gene- gene and gene-environment interactions that may underlie atypical brain functions in ASD. Project Status


Funder National Institutes of Health
Fiscal Year Funding $580,377.00
Current Award Period 2009-2014
Project Number 5R01MH067842-07
Principal Investigator Levitt, Pat
Received ARRA Funding? No
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Subcategory Molecular Pathways
Strategic Plan Objective 2O. Not specific to Question 2 objectives
Federal or Private? Federal
Institution University of Southern California
State/Country California
Web Link 1 Function and structure adaptations in forebrain development (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects Function and structure adaptations in forebrain development | $568,834.00 | 2009 | 2R01MH067842-06A1