Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Cell adhesion molecules in CNS development  

During brain development, cortical layers are established by the migration of newly born neurons from proliferative zones into the developing cortical wall and their incorporation into neuronal circuits. Disruption of the architecture of the neocortex is associated with more than 25 neurological disorders, including epilepsy, schizophrenia, autism, and mental retardation. Mutations in human cadherin genes, which encode a group of cell surface receptors enriched in the brain, have been linked to epilepsy, mental retardation, autism spectrum disorder, and Alzheimer disease. Using cell biological techniques, the researchers will examine how several members of the cadherin superfamily cooperate to regulate cell migration during neocortical development. Knowledge of how these receptors control migration will be relevant for understanding the mechanisms leading to pathological changes associated with several neurological disorders, including autism. Project Status


Funder National Institutes of Health
Fiscal Year Funding $541,105.00
Current Award Period 2010-2015
Project Number 2R01NS046456-06
Principal Investigator Mueller, Ulrich
Received ARRA Funding? No
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Subcategory Molecular Pathways
Strategic Plan Objective 2O. Not specific to Question 2 objectives
Federal or Private? Federal
Institution The Scripps Research Institute
State/Country California
Web Link 1 Cell adhesion molecules in CNS development (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects N/A