Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Met signaling in neural development and circuitry formation  

This is an NIH Pathway to Independence Award, which provides an opportunity for promising postdoctoral scientists to transition from mentored to independent research support. Human genetics studies have established MET as a risk gene for autism spectrum disorders. Met is a receptor tyrosine kinase, and this study investigates the mechanistic role of Met-mediated signaling in brain development and circuitry formation. This project will investigate role of Met signaling in the development and function of the hippocampus, determine molecular mechanisms regulating Met-induced neuronal growth and synaptogenesis in developing hippocampal neurons, and explore potential alterations in the local prefrontal cortex synaptic circuitry resulting from forebrain conditional Met deletion. These studies may provide mechanistic insights into Met-mediated signaling in forebrain development at molecular, cellular, and system levels. Insights gained from this study could offer better understanding of autism pathophysiology and thus be useful for future novel developmental interventions. Project Status


Funder National Institutes of Health
Fiscal Year Funding $81,998.00
Current Award Period 2010-2012
Project Number 1K99MH087628-01
Principal Investigator Qiu, Shenfeng
Received ARRA Funding? No
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Subcategory Molecular Pathways
Strategic Plan Objective 2O. Not specific to Question 2 objectives
Federal or Private? Federal
Institution University of Southern California
State/Country California
Web Link 1 Met signaling in neural development and circuitry formation (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects N/A