Project Detail
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Function of neurexins  

Synapses mediate the communication between nerve cells in brain and are impaired in cognitive diseases, such as autism and schizophrenia. Synapses are formed by cell-adhesion molecules including neurexins, which in recent studies have been implicated in schizophrenia and autism. In the present project, the researchers continue their long-term investigation of how neurexins function at synapses and how impairments of their function lead to cognitive diseases. The research aims utilize a combination of mouse genetics, electrophysiology, biophysics, and protein chemistry to determine the general functions of different neurexin isoforms. Results from this project will not only provide insight into how neurons communicate, but also promote our understanding of how such communication becomes dysfunctional in autism and schizophrenia. Project Status


Funder National Institutes of Health
Fiscal Year Funding $464,471.00
Current Award Period 2010-2015
Project Number 2R37MH052804-17
Principal Investigator Sudhof, Thomas
Received ARRA Funding? No
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Subcategory Molecular Pathways
Strategic Plan Objective 2O. Not specific to Question 2 objectives
Federal or Private? Federal
Institution Stanford University
State/Country California
Web Link 1 Function of neurexins (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects N/A