Project Detail
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Kinetics of drug macromolecule complex formation  

Researchers in this study are exploring the structure and function of three proteins, acetylcholinesterase, the nicotinic acetylcholine receptor, and neuroligin, all of which are structurally similar, located in the synapse, and play a role in neurotransmitter function. They are important potential drug targets and indicators of genetic predisposition to certain disorders in the nervous system, including autism. In particular, researchers will study genetic variants of neuroligin that have been found in autistic individuals in order to understand how the mutant protein behaves differently from the typical of wild-type version. These structural and functional studies offer new avenues into understanding the roles of these three proteins in physiological function and therapeutic outcomes. Project Status


Funder National Institutes of Health
Fiscal Year Funding $729,415.00
Current Award Period 2010-2013
Project Number 2R01GM018360-38A1
Principal Investigator Taylor, Palmer
Received ARRA Funding? No
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Subcategory Molecular Pathways
Strategic Plan Objective 2O. Not specific to Question 2 objectives
Federal or Private? Federal
Institution University of California, San Diego
State/Country California
Web Link 1 Kinetics of drug macromolecule complex formation (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects N/A