Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Structural and functional connectivity of large-scale brain networks in autism spectrum disorders  

This is a mentored Research Scientist Career Development Award for research and training support. The main goal of the proposed research is to examine aberrant structural and functional brain connectivity underlying atypical cognition and behavior in children with autism spectrum disorder (ASD). The candidate proposes to probe large-scale brain networks using diffusion tensor imaging (DTI) and functional magnetic resonance imaging (fMRI) to examine possible aberrant cortical connectivity and compromises in dynamic interactions between networks in children with ASD. The researcher will test the hypothesis that hypoactivity of the anterior insula during processing of social stimuli results in reduced salience detection in individuals with ASD, which impairs dynamic switching between other large-scale brain networks important for cognition. Additionally, methods to establish brain-based biomarkers to distinguish children with ASD from typically developing children using a combination of brain connectivity measures and cognitive and behavioral measures will be explored. Characterization of the integrity and functional roles of brain networks, as well as interactions between them, will help to understand the underlying brain differences in individuals with ASD and eventually lead to the development of more effective treatments and therapies. Project Status


Funder National Institutes of Health
Fiscal Year Funding $165,629.00
Current Award Period 2010-2015
Project Number 1K01MH092288-01
Principal Investigator Uddin, Lucina
Received ARRA Funding? No
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Subcategory Neural Systems
Strategic Plan Objective 2O. Not specific to Question 2 objectives
Federal or Private? Federal
Institution Stanford University
State/Country California
Web Link 1 Structural and functional connectivity of large-scale brain networks in autism spectrum disorders (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects N/A