Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Neural basis of behavioral flexibility  

Researchers will study the neural basis of behavior switching and stability, two processes that are disrupted in childhood autism and Parkinson's disease as evidenced by inappropriate initiation and repetition of movements. Motor behavior is determined not only by external stimuli but also by internal states of brain networks that function as sensory motor-integrators. An important type of network state is an experience-dependent state that relies on the memory of recent experiences. Consequently, to generate responses, networks integrate both current stimuli and memories of recent experiences that are expressed as network states. In this study, investigators will define how experience-dependent states are generated, expressed, and integrated with sensory stimuli in the brain using a multidisciplinary approach that combines electrophysiological, biochemical and cell-biological techniques. These studies may lead to novel insights into the nature of the behavioral deficits in these diseases, such as autism and Parkinson's disease. Project Status


Funder National Institutes of Health
Fiscal Year Funding $367,565.00
Current Award Period 2010-2015
Project Number 1R01NS070583-01
Principal Investigator Weiss, Klaudiusz; Cropper, Elizabeth
Received ARRA Funding? No
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Subcategory Sensory and Motor Function
Strategic Plan Objective 2O. Not specific to Question 2 objectives
Federal or Private? Federal
Institution Mount Sinai School of Medicine
State/Country New York
Web Link 1 Neural basis of behavioral flexibility (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects N/A