Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Statistical analysis of biomedical imaging data in curved space  

Many large-scale cross-sectional and longitudinal imaging studies have been or are being widely conducted to better understand the progress of neurodegenerative and neuropsychiatric disorders or normal brain development. This project will analyze imaging, behavioral, and clinical data from two large neuroimaging studies of schizophrenia and autism. The primary goal of this project is to develop new statistical tools and to evaluate these statistical tools for analysis of imaging data (e.g., diffusion tensor, deformation tensor, medial shape representation) in curved space, in combination with behavioral and clinical information in Euclidean space obtained from both cross-sectional and longitudinal studies. As these tools are developed, they will be evaluated and refined, and the efficacy of the tools developed under this grant will be tested by both simulated datasets and the two datasets including a longitudinal MRI study of schizophrenia and a longitudinal MRI study of autism, respectively. Moreover, the companion software for all developed statistical tools, once validated, will be disseminated to imaging researchers through This analysis software will provide much needed imaging tools for analyzing complex, correlated imaging data in biomedical, behavioral, and social sciences. Project Status


Funder National Institutes of Health
Fiscal Year Funding $330,008.00
Current Award Period 2010-2013
Project Number 1R01MH086633-01A1
Principal Investigator Zhu, Hongtu
Received ARRA Funding? No
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Subcategory Computational Science
Strategic Plan Objective 2O. Not specific to Question 2 objectives
Federal or Private? Federal
Institution University of North Carolina at Chapel Hill
State/Country North Carolina
Web Link 1 Statistical analysis of biomedical imaging data in curved space (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects N/A