Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Molecular pathways involved in oxidative stress and leaky gut impairment in autism spectrum disorders  

The main aim of this research is to investigate the relationship between the gastrointestinal tract and autism and understand how gut, brain, nutritional, and toxic status are consistent with greater oxidative stress in autistic spectrum disorders (ASD). Researchers will perform detailed analysis on peripheral blood mononuclear cells (PBMCs) and in the intestinal mucosa of ASD patients to identify several proteins and genes involved in inflammatory and cellular stress response as well as the innate and adaptive immunological response. In particular, researchers will study the molecular pathways responsible for apoptosis, inflammation, and cell damage or suffering of ASD-PBMCs. Project Status


Funder Autism Research Institute
Fiscal Year Funding $20,000.00
Current Award Period 2010
Project Number 2010-11
Principal Investigator Antonucci, Nicola
Received ARRA Funding? No
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Subcategory Immune/Metabolic Pathways
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 2SA. Support at least four research projects to identify mechanisms of fever, metabolic and/or immune system interactions with the central nervous system that may influence ASD during prenatal-postnatal life by 2010. IACC Recommended Budget: $9,800,000 over 4 years. (Fever studies to be started by 2012.)
Federal or Private? Private
Institution University of Naples
State/Country Italy
Web Link 1 Molecular pathways involved in oxidative stress and leaky gut impairment in autism spectrum disorders (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
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