Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Study of anti-neuronal autoantibodies in behavioral and movement disorders  

This study examines the cross reactive antibody specificities for dopamine receptors, tubulin, and lysoganglioside with antibody-mediated neuronal cell signaling mechanisms. The hypothesis for this research project is that autoantibody-mediated neuronal cell signaling may be present in sera and play a role in the development of PANDAS (pediatric autoimmune disorder associated with streptococcal infections), Sydenham chorea and related disorders. The project aims to determine the presence of and to understand mechanisms by which anti-neuronal autoantibodies (Ab) affect neuronal cells in vitro as well as the brain and consequently behavior in vivo. The findings will contribute to an understanding of autoimmune and signaling mechanisms which may be linked to infection and/or autoimmunity in movement and behavioral disorders and may bring us closer to more effective diagnosis and treatment. Studies will include patients with autism who demonstrate a PANDAS like syndrome. Project Status


Funder Autism Research Institute
Fiscal Year Funding $48,000.00
Current Award Period 2010
Project Number 2010-10
Principal Investigator Cunningham, Madeleine
Received ARRA Funding? No
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Subcategory Immune/Metabolic Pathways
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 2SA. Support at least four research projects to identify mechanisms of fever, metabolic and/or immune system interactions with the central nervous system that may influence ASD during prenatal-postnatal life by 2010. IACC Recommended Budget: $9,800,000 over 4 years. (Fever studies to be started by 2012.)
Federal or Private? Private
Institution University of Oklahoma Health Sciences Center
State/Country Oklahoma
Web Link 1 Study of anti-neuronal autoantibodies in behavioral and movement disorders (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
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