Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Primate models of autism  

This project is designed to provide additional support for the hypothesis that abnormal maternal autoantibodies may be one cause of autism. The study will build on preliminary results in rhesus monkeys that tested prenatal exposure to immunoglobulin G (IgG) class antibodies against human fetal brain tissue. This study will expand the number of test subjects and also increase the time period of antibody exposure into the second trimester on some subjects. The monkeys will then be followed for at least two years, evaluating behavioral development and performing longitudinal magnetic resonance imaging (MRI) scans. If maternal autoantibodies are identified as a risk factor for autism, this finding would quickly lead both to the development of a diagnostic assay for maternal autoantibodies and to the development of therapeutic interventions to diminish this autism risk factor. Project Status
ONGOING

2010

Funder National Institutes of Health
Fiscal Year Funding $734,756.00
Current Award Period 2008-2011
Project Number 5R01MH080218-03
Principal Investigator Bauman, Melissa; Amaral, David
Received ARRA Funding? No
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Subcategory Immune/Metabolic Pathways
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 2SA. Support at least four research projects to identify mechanisms of fever, metabolic and/or immune system interactions with the central nervous system that may influence ASD during prenatal-postnatal life by 2010. IACC Recommended Budget: $9,800,000 over 4 years. (Fever studies to be started by 2012.)
Federal or Private? Federal
Institution University of California, Davis
State/Country California
Web Link 1 Primate models of autism (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects Primate models of autism | $724,953.00 | 2009 | 5R01MH080218-02
Primate models of autism | $727,322.00 | 2008 | R01MH080218-01A2