Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Maternal immune activation, cytokines, and the pathogenesis of autism  

Although a wide range of environmental stimuli have been proposed to play a role in the pathogenesis of autism spectrum disorders (ASDs), many of these stimuli have in common the ability to alter immune function. Since cytokines mediate the immune response, are present in the developing brain, and regulate cortical plasticity and connectivity, factors that alter cytokines during development may lead to changes in synaptic connectivity that contribute to ASD. The goals of this proposal are to use a mouse model of maternal immune activation (MIA) to define the full complement of cytokines that are changed in specific regions of the central nervous system (CNS) of offspring at various postnatal ages following MIA and to determine the effects of those cytokines on connectivity and function in several cortical regions at the relevant postnatal ages. Project Status


Funder National Institutes of Health
Fiscal Year Funding $382,588.00
Current Award Period 2009-2011
Project Number 5R01MH088879-02
Principal Investigator McAllister, A. Kimberley
Received ARRA Funding? Yes
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Subcategory Immune/Metabolic Pathways
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 2SA. Support at least four research projects to identify mechanisms of fever, metabolic and/or immune system interactions with the central nervous system that may influence ASD during prenatal-postnatal life by 2010. IACC Recommended Budget: $9,800,000 over 4 years. (Fever studies to be started by 2012.)
Federal or Private? Federal
Institution University of California, Davis
State/Country California
Web Link 1 Maternal immune activation, cytokines, and the pathogenesis of autism (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects Maternal immune activation, cytokines, and the pathogenesis of autism | $378,570.00 | 2009 | 1R01MH088879-01