Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Project 2: Immunological susceptibility of autism  

Recent studies indicate that immune function in children with autism spectrum disorder (ASD) is profoundly altered compared to developmentally healthy controls. There is a strong interface between the immune system and the neurologic network, and successful neurodevelopment is contingent upon a successful interaction between these two systems. The study is one of three interrelated research projects at the University of California-Davis Center for Children's Environmental Health (CCEH) and will investigate both the serologic and cellular aspects of immune function in patients with autism to try to determine the underlying cellular mechanisms involved. From a cohort of children previously analyzed in the CHARGE study (Childhood Autism Risks from Genetics and Environment), children representing the entire ASD spectrum will be studied to evaluate the longitudinal serologic profile of children with ASD to determine which immune cell population(s) are crucial in the immune dysfunction seen in patients with autism and to fully characterize the autoantibody response in a subpopulation of children with ASD and some mothers of children with ASD. Project Status


Funder National Institutes of Health
Fiscal Year Funding $173,585.00
Current Award Period 2006-2013
Project Number 5P01ES011269-10
Principal Investigator Van de Water, Judy
Received ARRA Funding? No
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Subcategory Immune/Metabolic Pathways
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 2SA. Support at least four research projects to identify mechanisms of fever, metabolic and/or immune system interactions with the central nervous system that may influence ASD during prenatal-postnatal life by 2010. IACC Recommended Budget: $9,800,000 over 4 years. (Fever studies to be started by 2012.)
Federal or Private? Federal
Institution University of California, Davis
State/Country California
Web Link 1 Project 2: Immunological susceptibility of autism (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects Project 2: Immunological susceptibility of autism | $136,181.00 | 2009 | 5P01ES011269-09
Project 2: Immunological susceptibility of autism | $136,641.00 | 2008 | P01ES011269-08