Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Regulation of inflammatory Th17 cells in autism spectrum disorder  

Numerous studies suggest that abnormal activation of the immune system plays a role in causing autism. Some behavioral problems in children have been traced back to viral infections in their mothers during pregnancy. Studies in experimental mice have shown that revving up the mother's immune system during pregnancy results in offspring with altered gene expression in the brain and problems with behavioral development. More specifically, immune system changes and autoimmune disorders, such as inflammatory bowel disease, have been found in individuals with autism. Dan Littman and his colleagues at New York University School of Medicine suspect that the link between immune function and autism lies in a newly discovered subset of immune cells called Th17 cells. Th17 cells are so named because they produce the inflammation-inducing signaling molecule interleukin-17. Their normal role is thought to be in fighting bacterial and fungal infections, but if this defense mechanism goes awry, Th17 cells can cause inflammatory tissue damage that eventually leads to rheumatoid arthritis, multiple sclerosis, Crohn's disease, psoriasis and other autoimmune and inflammatory diseases. Littman and colleagues propose to study the contribution of these cells to autism using both mouse models and clinical samples. The researchers plan is to use experimental mice lacking Th17 cells to shed light on the cells' role in the behavioral changes linked to activation of the maternal immune system. The researchers also plan to examine the function of Th17 cells in mice lacking MeCP2, the gene that is defective in the autism-related Rett syndrome. Clinically, the researchers plan to compare levels of Th17 cells and the chemical signals they produce in blood samples from individuals with autism and healthy controls. They will also look at the distribution of other immune cells that can mediate inflammation. The findings from their study may strengthen understanding of the connection between autism and the immune system. Project Status
ONGOING

2010

Funder Simons Foundation
Fiscal Year Funding $112,500.00
Current Award Period 2008-2010
Project Number 95476
Principal Investigator Littman, Dan
Received ARRA Funding? No
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Subcategory Immune/Metabolic Pathways
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 2SA. Support at least four research projects to identify mechanisms of fever, metabolic and/or immune system interactions with the central nervous system that may influence ASD during prenatal-postnatal life by 2010. IACC Recommended Budget: $9,800,000 over 4 years. (Fever studies to be started by 2012.)
Federal or Private? Private
Institution New York University School of Medicine
State/Country New York
Web Link 1 Regulation of inflammatory Th17 cells in autism spectrum disorder (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects Regulation of inflammatory Th17 cells in autism spectrum disorder | $150,000.00 | 2009 | 95476