Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Investigation of sex differences associated with autism candidate gene, CYFIP1  

This is an individual National Research Service Award for pre-doctoral research training, which provides support for promising doctoral candidates who will be performing dissertation research and training in a scientific health-related field. Continued identification of genes associated with ASDs has advanced understanding of the role of genetics in ASDs, but the skewed sex ratio in prevalence remains unexplained. To this end, studying a candidate gene that shows sex differences in expression patterns or associated neural phenotypes may provide unique insights into ASD pathophysiology. Data from the Geschwind lab show that cytoplasmic FMRP-interacting protein 1 (CYFIP1) expression patterns differ by sex and that neuropathological phenotypes associated with Cyfip1 over-expression may also show sex differences. CYFIP1 has also been implicated in neural development and function, making this candidate gene a unique target for study. A transgenic mouse model that over-expresses Cyfip1 will be used to better understand the implications of the sex differences in Cyfip1 expression in neural development and ASD pathophysiology. Continued investigation along these lines will accelerate identification of those factors that cause males to be vulnerable to, or females to be protected from, ASDs, thereby facilitating the development of pharmaceutical treatments and preventive measures for ASDs. Project Status


Funder National Institutes of Health
Fiscal Year Funding $31,561.00
Current Award Period 2010-2014
Project Number 1F31MH093086-01
Principal Investigator Werling, Donna
Received ARRA Funding? No
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Subcategory Molecular Pathways
Strategic Plan Objective Yellow dot: Objective has some degree of funding, but less than the recommended amount. 2SB. Launch three studies that specifically focus on the neurodevelopment of females with ASD, spanning basic to clinical research on sex differences by 2011. IACC Recommended Budget: $8,900,000 over 5 years.
Federal or Private? Federal
Institution University of California, Los Angeles
State/Country California
Web Link 1 Investigation of sex differences associated with autism candidate gene, CYFIP1 (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
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