Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Neural circuit deficits in animal models of Rett syndrome  

Although autism spectrum disorder (ASD) is one of the most heritable cognitive disorders, the genetic causes of ASD remain uncertain. It is thought that ASD is caused by aberrant connections between neurons in the brain. It is not understood how multiple diverse genetic factors cause the common symptoms of ASD, but because many genes are involved in controlling the development of the neural circuits affected in ASD, mutations in any of multiple genes could lead to the disruption of these circuits. Understanding how neural circuitries are altered in animal models of ASD may provide insights into the etiology of this disorder. In the present study, Dr. Xiong will examine neural connectivity in a mouse model of autism. He will map short-range and long-range neural connections in the auditory cortex of mice lacking MeCP2, the gene mutated in Rett Syndrome, a genetic disorder which shares many common features with ASDs. Determining which neural pathways, when disrupted, produce the autistic-like behaviors seen in the MeCP2 mutant mouse should provide insight into the neural pathways disrupted in autism. Project Status


Funder Autism Speaks
Fiscal Year Funding $44,000.00
Current Award Period 2008-2010
Project Number 4849
Principal Investigator Xiong, Qiaojie
Received ARRA Funding? No
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Subcategory Molecular Pathways
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 2SD. Launch three studies that target improved understanding of the underlying biological pathways of genetic conditions related to autism (e.g. Fragile X, Rett syndrome, tuberous sclerosis complex) and how these conditions inform risk assessment and individualized intervention by 2012. IACC Recommended Budget: $9,000,000 over 5 years.
Federal or Private? Private
Institution Cold Spring Harbor Laboratory
State/Country New York
Web Link 1 Neural circuit deficits in animal models of Rett syndrome (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects Neural circuit deficits in animal models of Rett syndrome | $0.00 | 2009 | 4849
Neural circuit deficits in animal models of Rett syndrome | $44,000.00 | 2008 | 4849