Non-coding RNAs (ncRNAs) of the embryonic ventral forebrain (Evf) are the first developmentally regulated ncRNAs to be discovered that affect the transcriptional activity of a homeodomain protein. In this study, investigators hope to gain a better understanding of this novel mechanism of RNA-dependent transcriptional regulation. The importance of mechanistic studies of RNA function is clear from the number of regulatory RNAs thought to be involved different diseases. These include: the autism-related disorders Prader Willi Syndrome and diGeorge Syndrome, as well as Beckwith-Wiedeman syndrome, Spinocerebellar ataxia type 8, and campomelic dysplasia. The investigators hypothesize that Evfs regulate Dlx 1/2 genes, which are known to modulate the inhibitory GABAergic pathway in the brain. Alterations in Dlx 5 have been linked to Rett syndrome, affecting specific aspects of GABAergic interneuron differentiation or migration. Since altered GABAergic interneuron function has been linked to epilepsy, autism, schizophrenia, and mental retardation, studies on the normal development of GABAergic interneurons are critical to understanding the molecular bases for these diseases. Ultimately, researchers hope that a better understanding of the normal development of specific neuronal subpopulations in the brain will lead to the prevention and treatment of human neurological diseases.