Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

The role of MeCP2 in Rett syndrome  

Rett syndrome has been considered a "Rosetta stone" for deciphering the complex genetics of autism because it is the only one of the five pervasive developmental disorders with a known genetic cause. This proposal seeks to understand how the product of the Rett gene, MeCP2, operates inside the nuclei of post-natal neurons to regulate important gene regulatory events in learning and memory. Project Status


Funder National Institutes of Health
Fiscal Year Funding $337,753.00
Current Award Period 2008-2012
Project Number 5R01HD041462-08
Principal Investigator LaSalle, Janine
Received ARRA Funding? No
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Subcategory Molecular Pathways
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 2SD. Launch three studies that target improved understanding of the underlying biological pathways of genetic conditions related to autism (e.g. Fragile X, Rett syndrome, tuberous sclerosis complex) and how these conditions inform risk assessment and individualized intervention by 2012. IACC Recommended Budget: $9,000,000 over 5 years.
Federal or Private? Federal
Institution University of California, Davis
State/Country California
Web Link 1 The role of MeCP2 in Rett syndrome (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects The role of MECP2 in Rett syndrome | $308,949.00 | 2009 | 5R01HD041462-07
The role of MECP2 in Rett syndrome | $251,626.00 | 2008 | R01HD041462-06A2
The role of MECP2 in Rett syndrome (supplement) | $34,417.00 | 2009 | 3R01HD041462-07S1
The role of MECP2 in Rett syndrome - Supplement | $47,769.00 | 2008 | R01HD041462-06A2S1