Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Olfactory abnormalities in the modeling of Rett syndrome  

Rett Syndrome (RTT) is an autism spectrum disorder (ASD) that results in mental retardation, motor dysfunction, seizures, and features of autism. RTT is caused by mutation of MeCP2, a gene that affects brain gene expression, and a type of mutation that may underlie many ASDs. Little is known about the specific neurodevelopmental defects that underlie the complex clinical course of RTT. This research will use the olfactory system and mouse models of MeCP2 mutation to define the mechanisms that underlie the biological defects incurred by MeCP2 dysfunction to clarify the basis for neuronal compromise in ASDs. Project Status


Funder National Institutes of Health
Fiscal Year Funding $355,163.00
Current Award Period 2009-2013
Project Number 5R01NS041079-07
Principal Investigator Ronnett, Gabriele
Received ARRA Funding? No
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Subcategory Molecular Pathways
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 2SD. Launch three studies that target improved understanding of the underlying biological pathways of genetic conditions related to autism (e.g. Fragile X, Rett syndrome, tuberous sclerosis complex) and how these conditions inform risk assessment and individualized intervention by 2012. IACC Recommended Budget: $9,000,000 over 5 years.
Federal or Private? Federal
Institution Johns Hopkins University
State/Country Maryland
Web Link 1 Olfactory abnormalities in the modeling of Rett syndrome (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects Olfactory abnormalities in the modeling of Rett syndrome | $358,750.00 | 2009 | 2R01NS041079-06A2