Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Sex differences in early brain development; Brain development in Turner syndrome  

This is a mentored research scientist development award to support an intensive, supervised career development experience in the biomedical, behavioral, or clinical sciences leading to research independence. The trainee will study developmental mechanisms in the autism-related disorder Turner syndrome, a well-defined genetic disorder resulting from the partial or complete loss of one of the sex chromosomes. Currently, very little is known about sexual dimorphism in early development, and it is unclear why autism is more prevalent in males than females, though researchers have hypothesized X- chromosome effects and early exposure to gonadal hormones may play a causal role. In this longitudinal study, brain imaging techniques like magnetic resonance imaging (MRI) will be used to characterize brain development in typically developing children and children with Turner syndrome followed from birth to 2 years of age. Results will provide new information on brain-specific sex differences in the developing brain and a better understanding of brain abnormalities in Turner syndrome. Project Status


Funder National Institutes of Health
Fiscal Year Funding $153,382.00
Current Award Period 2008-2013
Project Number 5K01MH083045-03
Principal Investigator Santelli, Rebecca
Received ARRA Funding? No
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Subcategory Developmental Trajectory
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 2SD. Launch three studies that target improved understanding of the underlying biological pathways of genetic conditions related to autism (e.g. Fragile X, Rett syndrome, tuberous sclerosis complex) and how these conditions inform risk assessment and individualized intervention by 2012. IACC Recommended Budget: $9,000,000 over 5 years.
Federal or Private? Federal
Institution University of North Carolina at Chapel Hill
State/Country North Carolina
Web Link 1 Sex differences in early brain development; Brain development in Turner syndrome (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects Sex differences in early brain development; Brain development in Turner Syndrome | $147,884.00 | 2008 | K01MH083045-01