Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

New approaches to local translation: SpaceSTAMP of proteins synthesized in axons  

Protein translation was not thought to occur in axons, but more recent data has provided evidence that many mRNAs are found in axons in the mammalian nervous system. Evidence indicating that local translation in axons may be regulated by electrical activity, neurotrophic factors, and stress has led to the hypothesis that axonal translation is particularly important for plasticity during learning or in response to environmental stressors. In support of this idea, defects in local translation have been linked to fragile X syndrome, which causes cognitive problems and autistic behaviors, but the mechanisms are not understood. To address this problem, these studies will develop a new technique called spaceSTAMP. This technique allows one to tag proteins made in one part of the cell and to follow these components as they move in time and space. The goal of this proposal is develop the spaceSTAMP approach and use it to ask: Is there regulated local translation in axons? Are such locally translated proteins functionally important? Are locally translated proteins restricted to the axonal compartment, or do they facilitate communication between axonal terminals and remote portions of the neuronal cell body? Once spaceSTAMP has been developed, this approach can be used by the scientific community to solve problems such as the functional importance of the fragile X gene product and ways in which activity or neurotrophin regulated translation contribute to neuro-psychiatric disorders. Project Status


Funder National Institutes of Health
Fiscal Year Funding $161,094.00
Current Award Period 2010-2014
Project Number 1R01MH091662-01
Principal Investigator Segal, Rosalind
Received ARRA Funding? No
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Subcategory Molecular Pathways
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 2SD. Launch three studies that target improved understanding of the underlying biological pathways of genetic conditions related to autism (e.g. Fragile X, Rett syndrome, tuberous sclerosis complex) and how these conditions inform risk assessment and individualized intervention by 2012. IACC Recommended Budget: $9,000,000 over 5 years.
Federal or Private? Federal
Institution Dana-Farber Cancer Institute
State/Country Massachusetts
Web Link 1 New approaches to local translation: SpaceSTAMP of proteins synthesized in axons (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects N/A