Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Neurogenic growth factors in autism  

In addition to their prominent role in certain types of cancer, genes in the fibroblast growth factor (FGF) pathway have been shown in animal models to be important for brain development. Animals with mutations in FGF genes, for instance, exhibit anatomical characteristics reminiscent of those observed in autism. Dr. Vaccarino plans to investigate these genes for variants associated with autism. Using samples she collected as well as those from Autism Genetic Resource Exchange (AGRE), she also plans to correlate changes in these genes associated with autism with changes in brain size and structures. Project Status


Funder Autism Speaks
Fiscal Year Funding $112,494.00
Current Award Period 2007-2011
Project Number 1883
Principal Investigator Vaccarino, Flora
Received ARRA Funding? No
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Subcategory Subgroups/Biosignatures
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 2SG. Support five studies that associate specific genotypes with functional or structural phenotypes, including behavioral and medical phenotypes (e.g., nonverbal individuals with ASD and those with cognitive impairments) by 2015. IACC Recommended Budget: $22,600,000 over 5 years.
Federal or Private? Private
Institution Yale University
State/Country Connecticut
Web Link 1 Neurogenic growth factors in autism (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects Neurogenic growth factors in autism | $0.00 | 2009 | 1883
Neurogenic growth factors in autism | $150,000.00 | 2008 | 1883
Neurogenic growth factors in autism | $0.00 | 2011 | 1883