Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Autistic traits: Life course & genetic structure  

Autism and related disorders affect 1 out of every 150 children in the US and result in profound social impairment throughout life. This study examines how autistic social impairments change over the course of childhood, how they are transmitted across generations, and which normal developmental processes they disrupt. The results of the study will aid in the search for the genes and neural abnormalities that cause autism, will enhance methods for measuring subtle but important effects of intervention, and will identify intervals in the lifespan when interventions might have their greatest impact on social development in affected children. Project Status


Funder National Institutes of Health
Fiscal Year Funding $547,284.00
Current Award Period 2008-2013
Project Number 5R01HD042541-08
Principal Investigator Constantino, John
Received ARRA Funding? No
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Subcategory Developmental Trajectory
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 2SG. Support five studies that associate specific genotypes with functional or structural phenotypes, including behavioral and medical phenotypes (e.g., nonverbal individuals with ASD and those with cognitive impairments) by 2015. IACC Recommended Budget: $22,600,000 over 5 years.
Federal or Private? Federal
Institution Washington University
State/Country Missouri
Web Link 1 Autistic traits: Life course & genetic structure (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects Autistic traits: Life course & genetic structure | $573,470.00 | 2009 | 5R01HD042541-07
Autistic traits: Life course & genetic structure | $540,190.00 | 2008 | R01HD042541-06A1