Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

ACE Center: Genetics of serotonin in autism: Neurochemical and clinical endophenotypes  

This grant provides support for an NIH Autism Center of Excellence (ACE). Neurochemical, behavioral, and genetic evidence implicate serotonin dysfunction in autism, specifically in restricted and repetitive behaviors (RRBs). Recently described mutations in a serotonin transporter gene reveal a common pattern of elevated serotonin transporter activity and a phenotype of autism with RRBs or obsessive compulsive disorder. In this research project, twenty-five serotonin related genes will be studied in 250 ASD children rigorously screened using ACE and Autism Diagnostic Interview, Revised (ADI-R) criteria to determine association with autism, specifically for Insistence on Sameness (IS). Project Status


Funder National Institutes of Health
Fiscal Year Funding $382,540.00
Current Award Period 2007-2012
Project Number 5P50HD055751-04
Principal Investigator Cook, Edwin
Received ARRA Funding? No
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Subcategory Subgroups/Biosignatures
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 2SG. Support five studies that associate specific genotypes with functional or structural phenotypes, including behavioral and medical phenotypes (e.g., nonverbal individuals with ASD and those with cognitive impairments) by 2015. IACC Recommended Budget: $22,600,000 over 5 years.
Federal or Private? Federal
Institution University of Illinois at Chicago
State/Country Illinois
Web Link 1 ACE Center: Genetics of serotonin in autism: Neurochemical and clinical endophenotypes (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects Not available at this time. This functionality is experimental.