Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

A family-genetic study of language in autism  

Strong evidence supports a genetic component in autism, and twin and family studies have also shown that genetic liability appears to be expressed among unaffected relatives of people with autism through features that are milder, but qualitatively similar, to the defining characteristics of autism. Therefore, studies of relatives of individuals with autism can help to simplify the complex autism phenotype and identify component traits which are more amenable to genetic dissection than the full clinical syndrome. In this study, investigators will employ a battery of measures to define language processing abilities among individuals with autism and their relatives. The primary goal of this work is to identify genetically meaningful autism language phenotypes. Results will provide quantitative measures that may then be used in genetic studies and which could be targeted in clinical intervention efforts. Research aimed at uncovering the pathogenesis of autism may lead to evidence-based approaches to prevention or treatment. Project Status


Funder National Institutes of Health
Fiscal Year Funding $321,304.00
Current Award Period 2010-2015
Project Number 7R01DC010191-02
Principal Investigator Losh, Molly
Received ARRA Funding? No
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Subcategory Subgroups/Biosignatures
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 2SG. Support five studies that associate specific genotypes with functional or structural phenotypes, including behavioral and medical phenotypes (e.g., nonverbal individuals with ASD and those with cognitive impairments) by 2015. IACC Recommended Budget: $22,600,000 over 5 years.
Federal or Private? Federal
Institution Northwestern University
State/Country Illinois
Web Link 1 A family-genetic study of language in autism (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects A family-genetic study of language in autism | $208,064.00 | 2010 | 1R01DC010191-01A1