Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

ACE Center: Genetic contributions to endophenotypes of autism  

This grant provides support for an NIH Autism Center of Excellence (ACE). Early autism risk factors (genetics, familial, and environmental) lead to altered patterns of interaction between the child and his/her environment, which, in turn, can contribute to the abnormal development of neural circuitry and atypical behavior. This project has two major goals. First, it will identify autism susceptibility genes and their genomic location(s): genes in which variation affects risk for autism spectrum disorders (ASD). Second, it will seek to expand the set of component traits (endophenotypes) for which there is evidence for a genetic basis. The study will use an existing sample of families that have multiple members with an ASD diagnosis and also recruit additional relatives to identify genomic regions with ASD risk genes. Identification of susceptibility genes will lead to identification of underlying biological mechanisms and offers the promise of presymptomatic diagnosis and, ultimately, of disease-modifying medications or other therapies for use early in disease and during the presymptomatic period. Project Status


Funder National Institutes of Health
Fiscal Year Funding $569,673.00
Current Award Period 2007-2012
Project Number 5P50HD055782-04
Principal Investigator Wijsman, Ellen
Received ARRA Funding? No
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Subcategory Subgroups/Biosignatures
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 2SG. Support five studies that associate specific genotypes with functional or structural phenotypes, including behavioral and medical phenotypes (e.g., nonverbal individuals with ASD and those with cognitive impairments) by 2015. IACC Recommended Budget: $22,600,000 over 5 years.
Federal or Private? Federal
Institution University of Washington
State/Country Washington
Web Link 1 ACE Center: Genetic contributions to endophenotypes of autism (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects ACE Center: Genetic contributions to endophenotypes of autism | $576,375.00 | 2009 | 5P50HD055782-03