Project Detail
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Language processing in children with 22q11 deletion syndrome and autism  

Children with autism spectrum disorders have impaired language and communication development, but the severity of these problems varies greatly between individuals. A new study by Opal Ousley at Emory University is aimed at uncovering the root of this variation, based on the hypothesis that some communication deficiencies are unique to autism, whereas others result from an underlying genetic syndrome. Ousley's study will focus on children with 22q11 deletion syndrome, which occurs when a small piece of chromosome 22 is missing. The chromosomal defect is associated with language delay and difficulties in phonology, and has been strongly linked to autism spectrum disorders. The study will include three groups: children who have the genetic syndrome but do not have autism, children affected with both the genetic syndrome and autism, and children who have autism with no known genetic cause. The researchers plan to assess elementary-school children twice for short-term changes in their processing of single words, ability to remember words after hearing them, and more complex forms of verbal expression. By comparing the three groups of children, Ousley hopes to learn whether language progression is impaired differently in children with autism with the genetic defect, and whether this impairment could be a red flag for autism in other children with the defect. Expanded studies could then track language development across other genetic subgroups of autism. The findings from this study may facilitate earlier detection of autism and more accurate prognosis of language development and may ultimately result in better educational guidelines and interventions for parents and teachers of children with autism. Project Status


Funder Simons Foundation
Fiscal Year Funding $30,000.00
Current Award Period 2008-2011
Project Number 89637
Principal Investigator Ousley, Opal
Received ARRA Funding? No
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Subcategory Subgroups/Biosignatures
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 2SG. Support five studies that associate specific genotypes with functional or structural phenotypes, including behavioral and medical phenotypes (e.g., nonverbal individuals with ASD and those with cognitive impairments) by 2015. IACC Recommended Budget: $22,600,000 over 5 years.
Federal or Private? Private
Institution Emory University
State/Country Georgia
Web Link 1 Language processing in children with 22q11 deletion syndrome and autism (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects Language processing in children with 22q11 deletion syndrome and autism | $120,000.00 | 2009 | 89637
Language processing in children with 22q11 deletion syndrome and autism | $150,000.00 | 2008 | Project number unavailable