Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Potential role of non-coding RNAs in autism  

Genetic predisposition to autism may involve both differences in the coding regions of DNA (genomic regions encoding RNAs which are eventually translated into proteins) and changes in the regulation of gene expression, though the coding regions of DNA are unaffected. A recently discovered mechanism for the regulation of gene expression is non-coding RNAs (RNAs which do not get translated into proteins). Non-coding RNAs may regulate the translation of other RNAs to proteins. Changes in expression of these non-coding RNAs could potentially be involved in the development of autism. This study aims to characterize the non-coding RNAs present in autistic individuals compared to normal individuals. Researchers will use microarray technology capable of measuring the levels of thousands of individual RNAs to identify which non-coding RNAs are expressed at different levels in blood cells from autistic versus non-autistic subjects. Examining non-coding RNAs is a novel approach to discovering the biological mechanisms underlying autism and may identify novel drug targets for the treatment and prevention of autism. Project Status


Funder Autism Speaks
Fiscal Year Funding $0.00
Current Award Period 2008-2011
Project Number 2578
Principal Investigator Talebizadeh, Zohreh
Received ARRA Funding? No
Strategic Plan Question Question 3: What Caused This To Happen And Can This Be Prevented? (Causes)
Subcategory Genetic Risk Factors
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 3LB. Identify genetic risk factors in at least 50% of people with ASD by 2014. IACC Recommended Budget: $33,900,000 over 6 years.
Federal or Private? Private
Institution Children's Mercy Hospitals And Clinics
State/Country Missouri
Web Link 1 Potential role of non-coding RNAs in autism (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects Potential role of non-coding RNAs in autism | $59,989.00 | 2009 | 2578
Potential role of non-coding RNAs in autismĀ  | $0.00 | 2011 | 2578