Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Genetic epidemiology of complex traits  

In this NIH Intramural Research Program (IRP), researchers are examining potential genetic contributions to a wide variety of disorders, including autism, attention deficit hyperactivity disorder (ADHD), eye disorders (i.e., glaucoma, myopia), and rare neurological syndromes. In their genetic study of autism, researchers have found evidence for a genetic linkage of autistic individuals with hypocholesterolemia, which is defined by the presence of abnormally low (hypo-) levels of cholesterol in the blood (-emia). Confirmation in additional data is underway, and additional family data are being collected. Whole-exome sequencing of autistic patients with extreme cholesterol values and a sibling with either autism or autism spectrum disorder (ASD) is being performed to search for rare variants of large effect in this subset of patients with familial autism/ASD. This study will also be extended to include autistic patients with extreme hypocholesterolemia but who do not have siblings affected with ASD. Project Status
ONGOING

2010

Funder National Institutes of Health
Fiscal Year Funding $770,313.00
Current Award Period Ongoing
Project Number 1ZIAHG200327-06
Principal Investigator Bailey-Wilson, Joan
Received ARRA Funding? No
Strategic Plan Question Question 3: What Caused This To Happen And Can This Be Prevented? (Causes)
Subcategory Genetic Risk Factors
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 3LB. Identify genetic risk factors in at least 50% of people with ASD by 2014. IACC Recommended Budget: $33,900,000 over 6 years.
Federal or Private? Federal
Institution National Institutes of Health
State/Country Maryland
Web Link 1 Genetic epidemiology of complex traits (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
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