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Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Gene-environment interactions in an autism birth cohort (supplement)  

This is a supplement to a previously awarded grant with the same title. Reports of increasing prevalence of autism spectrum disorders (ASDs) are intensifying interest in the role of environmental exposures, including infectious, immune, and toxic factors. This prospective study will employ the Autism Birth Cohort (ABC), a smaller cohort (ASD, N=150-233) selected from the Norway Mothers and Child (MoBa) study, which consists of 75,500 Norwegian mother-child pairs. In the ABC study, children meeting criteria for an autism diagnosis are ascertained through screening of the entire population with diagnoses established using uniform procedures. In addition to an autism diagnosis, extensive histories and clinical data are obtained and biologic samples are collected serially throughout pregnancy and early childhood. Researchers in this study aim to identify gene-environment factors contributing to the development of autism, including: 1) immune, endocrine, and neuroregulatory factors in mothers during early gestation or at birth, 2) environmental factors, including pre- or postnatal infection, vaccination, very low birth weight or other obstetric risk factors, dietary and/or environmental exposure to methylmercury, and 3) genotypic influences that are associated with a family history of autoimmune disease or other ASD candidate genes. The Norwegian ABC study offers an unprecedented, rich view of the longitudinal trajectory and nascent signs and symptoms of autism spectrum disorders, facilitating discovery of biomarkers and gene-environment interactions in ASD pathogenesis. Project Status


Funder National Institutes of Health
Fiscal Year Funding $849,819.00
Current Award Period 2010-2011
Project Number 3U01NS047537-05S1
Principal Investigator Lipkin, W. Ian
Received ARRA Funding? No
Strategic Plan Question Question 3: What Caused This To Happen And Can This Be Prevented? (Causes)
Subcategory Gene-Environment
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 3LD. Support ancillary studies within one or more large-scale, population-based surveillance and epidemiological studies, including U.S. populations, to collect data on environmental factors during preconception, and during prenatal and early postnatal development, as well as genetic data, that could be pooled (as needed), to analyze targets for potential gene/environment interactions by 2015. IACC Recommended Budget: $44,400,000 over 5 years.
Federal or Private? Federal
Institution Columbia University
State/Country New York
Web Link 1 Gene-environment interactions in an autism birth cohort (supplement) (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects N/A