Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Large-scale discovery of scientific hypotheses; Computation over expert opinions  

Many fields of modern biomedicine have a plurality of theoretical views but most remain unknown to the majority, eclipsed by a dominant perspective that disproportionately attracts funds, journal page-space, and attention. This often unwarranted narrowness of focus is particularly disturbing in fields devoted to the biology and cure of complex maladies such as autism, schizophrenia, diabetes, and breast cancer, where a multiplicity of genetic and environmental influences likely play a role. This project aims to accelerate scientific discovery by drawing attention to hypotheses, hunches, and theory-specific evidence beyond the dominant paradigm(s) of the field. The process includes searching for scientific hunches and findings from a diverse range of sources, synthesizing new hypotheses and formalizing them into a composite reasoning model, computing the probability of each hypothesis, and disseminating findings back to the scientific community to stimulate discourse and advances. The goal is to improve the odds and speed of theory development without explicitly demanding more experimental resources. Project Status


Funder National Institutes of Health
Fiscal Year Funding $607,996.00
Current Award Period 2009-2011
Project Number 5R01LM010132-02
Principal Investigator Rzhetsky, Andrey; Evans, James; Foster, Ian
Received ARRA Funding? Yes
Strategic Plan Question Question 3: What Caused This To Happen And Can This Be Prevented? (Causes)
Subcategory Gene-Environment
Strategic Plan Objective 3O. Not specific to Question 3 objectives
Federal or Private? Federal
Institution University of Chicago
State/Country Illinois
Web Link 1 Large-scale discovery of scientific hypotheses; Computation over expert opinions (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects Large-scale discovery of scientific hypotheses; Computation over expert opinions | $603,044.00 | 2009 | 1R01LM010132-01