Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Early exposure to acetaminophen and autism  

The proposed project will serve as a pilot study to assess feasibility of conducting a full investigation of whether intake of acetaminophen or other analgesics in early childhood is a risk factor for autism/ASD. Both the pilot and, if appropriate, the full study, will take advantage of data that have been generated from The CHARGE (Childhood Autism Risks from Genetics and the Environment) Study, an ongoing NIEHS-funded population based case-control study of children with autism or ASD, children with developmental delay but neither autism nor ASD, and typically developing controls recruited from the general population. For the pilot study, we will focus on a subset of cases of autism or ASD and a similar subset of typically developing controls and their early childhood medical information, including infections, fever, and use of acetaminophen, aspirin, and ibuprofen. Sources of data on intake of these medications and on their indications are primarily the maternal reports and pediatric records. These will be supplemented by product information to capture the wide range of over-the-counter treatments that may contain acetaminophen, aspirin or ibuprofen as an adjunct ingredient. The pilot study will evaluate the feasibility of obtaining a relatively comprehensive picture of exposures. In the full study, prevalence odds ratios will be calculated for each of these exposures in logistic regression models adjusting appropriately for sociodemographic, medical, and other potentially confounding variables. Project Status


Funder Autism Speaks
Fiscal Year Funding $19,997.00
Current Award Period 2010-2011
Project Number 7489
Principal Investigator Hertz-Picciotto, Irva
Received ARRA Funding? No
Strategic Plan Question Question 3: What Caused This To Happen And Can This Be Prevented? (Causes)
Subcategory Environment
Strategic Plan Objective Yellow dot: Objective has some degree of funding, but less than the recommended amount. 3SF. Initiate studies on at least 10 environmental factors identified in the recommendations from the 2007 IOM report "Autism and the Environment: Challenges and Opportunities for Research" as potential causes of ASD by 2012. Estimated cost $56,000,000 over 2 years.
Federal or Private? Private
Institution University of California, Davis
State/Country California
Web Link 1 Early exposure to acetaminophen and autism (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects Not available at this time. This functionality is experimental.