Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Structural and functional neural correlates of early postnatal deprivation  

This is a Clinical Investigator Award, providing an opportunity for a medical investigator to develop into an independent researcher. Despite links between early postnatal deprivation (ESD) and neuropsychological problems, few studies have investigated whether the neural substrates thought to underlie such functions are abnormal in children with such histories. The overarching aim of the proposed studies is to probe, with imaging techniques, the structural and functional neurobiological consequences of ESD. The approach of integrating magnetic resonance imaging (MRI) and positron emission tomography (PET) methods with neuropsychological assessments is innovative and will yield new and important data on children exposed to ESD. These studies have potential translational value, as neuroimaging data can be used to monitor effects of therapeutic interventions and to assess the potential reversibility of findings, which has not been possible in the past. Project Status


Funder National Institutes of Health
Fiscal Year Funding $150,412.00
Current Award Period 2007-2012
Project Number 5K08MH079176-04
Principal Investigator Behen, Michael
Received ARRA Funding? No
Strategic Plan Question Question 3: What Caused This To Happen And Can This Be Prevented? (Causes)
Subcategory Environment
Strategic Plan Objective New! Yellow dot: Objective has some degree of funding, but less than the recommended amount. 3SH. Support at least three studies of special populations or use existing databases to inform our understanding of environmental risk factors for ASD in pregnancy and the early postnatal period by 2012. Such studies could include: o Comparisons of populations differing in geography, gender, ethnic background, exposure history (e.g., prematurity, maternal infection, nutritional deficiencies, toxins), and migration patterns; and o Comparisons of phenotype (e.g., cytokine profiles), in children with and without a history of autistic regression, adverse events following immunization (such as fever and seizures), and mitochondrial impairment. These studies may also include comparisons of phenotype between children with regressive ASD and their siblings. oEmphasis on environmental factors that influence prenatal and early postnatal development is particularly of high priority. Epidemiological studies should pay special attention to include racially and ethnically diverse populations. IACC Recommended Budget: $12,000,000 over 5 years.
Federal or Private? Federal
Institution Wayne State University
State/Country Michigan
Web Link 1 Structural and functional neural correlates of early postnatal deprivation (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects Structural and functional neural correlates of early postnatal deprivation | $148,768.00 | 2009 | 5K08MH079176-03
Structural and functional neural correlates of early postnatal deprivation | $145,003.00 | 2008 | K08MH079176-02