Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Elevated urinary P-cresol: Intestinal causes and behavioral consequences  

This study examines clostridia and para-cresol in individuals with ASD. Initial research studies demonstrate a significant increase in urinary p-cresol concentrations among ASD patients compared with matched controls. Urinary p-cresol cannot derive from human metabolism; it can either stem from the presence of clostridium difficile in the gut or from toxic contamination with p-cresol-containing hydrocarbon mixtures. Excess urinary p-cresol may originate from abnormal gut flora or excessive gut permeability in children with ASD. This study intends to define the degree of overlap between elevated urinary p-cresol, clostridial gut infection, and enhanced intestinal permeability. The correlation between urinary p-cresol and a clinical history of regression will also be examined in study subjects. Finally, preliminary experiments will be conducted on approximately 12 young and adult rodents by injecting p-cresol to assess whether and to what extent p-cresol can influence the development and/or function of the central nervous system. Project Status


Funder Autism Research Institute
Fiscal Year Funding $25,000.00
Current Award Period 2010
Project Number 2010-8
Principal Investigator Persico, Antonio
Received ARRA Funding? No
Strategic Plan Question Question 3: What Caused This To Happen And Can This Be Prevented? (Causes)
Subcategory Environment
Strategic Plan Objective New! Yellow dot: Objective has some degree of funding, but less than the recommended amount. 3SI. Support at least two studies that examine potential differences in the microbiome of individuals with ASD versus comparison groups by 2012. IACC Recommended Budget: $1,000,000 over 2 years.
Federal or Private? Private
Institution Universita Campus Bio-Medico di Roma
State/Country Italy
Web Link 1 Elevated urinary P-cresol: Intestinal causes and behavioral consequences (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects N/A