Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Epigenetic marks as peripheral biomarkers of autism  

Autism is a common disorder whose causes are poorly understood. Both genetic and environmental influences are thought to act together causing autism. Epigenetics is an area that bridges genetic and environmental factors and commonly is studied by examining dynamic methylation changes to the DNA. Prior research screened a total of 78 autistic boys and their fathers by this method in 807 genes and found 116 methylation changes that together can correctly identify nearly 80% of the affected boys from their fathers. In this study, these data will be confirmed in a much larger set of genes in 1,200 autistic boys and their families, including unaffected brothers. These data not only could provide new insight into the causes of autism but could also result in a screening test for autism. Project Status


Funder National Institutes of Health
Fiscal Year Funding $949,623.00
Current Award Period 2009-2011
Project Number 5R01MH089606-02
Principal Investigator Warren, Stephen
Received ARRA Funding? Yes
Strategic Plan Question Question 3: What Caused This To Happen And Can This Be Prevented? (Causes)
Subcategory Epigenetics
Strategic Plan Objective New! Green dot: Objective has greater than or equal to the recommended funding. 3SJ. Support at least three studies that focus on the role of epigenetics in the etiology of ASD, including studies that include assays to measure DNA methylations and histone modifications and those exploring how exposures may act on maternal or paternal genomes via epigenetic mechanisms to alter gene expression, by 2012. IACC Recommended Budget: $20,000,000 over 5 years.
Federal or Private? Federal
Institution Emory University
State/Country Georgia
Web Link 1 Epigenetic marks as peripheral biomarkers of autism (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects Epigenetic marks as peripheral biomarkers of autism | $2,198,844.00 | 2009 | 1R01MH089606-01