Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Project 3: Neurodevelopmental toxicology of autism  

The goal of this project (one of three interrelated projects at the University of California-Davis Center for Children's Environmental Health (CCEH) is to determine if exposure to environmental toxicants early in development contributes to the etiology of neurodevelopmental disorders such as autism. A related goal is to determine whether susceptibility to autoimmune disease increases the neurotoxicity of environmental contaminants and increases the risk for developing disorders such as autism. The study will expose mouse strains with low or high susceptibility to autoimmunity perinatally to either methylmercury, polychlorinated biphenyl 95, or polybrominated diphenyl ether 47. The effects of toxicant exposure between these mouse strains on brain development, complex social behaviors, and immune system function will then be compared. Understanding how exposure to environmental toxicants may contribute to the etiology of neurodevelopmental disorders is important so that the exposure risks can be identified and minimized. Project Status


Funder National Institutes of Health
Fiscal Year Funding $173,583.00
Current Award Period 2006-2013
Project Number 5P01ES011269-10
Principal Investigator Pessah, Isaac
Received ARRA Funding? No
Strategic Plan Question Question 3: What Caused This To Happen And Can This Be Prevented? (Causes)
Subcategory Environment
Strategic Plan Objective New! Green dot: Objective has greater than or equal to the recommended funding. 3SK. Support two studies and a workshop that facilitate the development of vertebrate and invertebrate model systems for the exploration of environmental risks and their interaction with gender and genetic susceptibilities for ASD by 2012. IACC Recommended Budget: $1,535,000 over 3 years.
Federal or Private? Federal
Institution University of California, Davis
State/Country California
Web Link 1 Project 3: Neurodevelopmental toxicology of autism (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects Project 3: Neurodevelopmental toxicology of autism | $136,181.00 | 2009 | 5P01ES011269-09
Project 3: Neurodevelopmental toxicology of autism | $136,640.00 | 2008 | P01ES011269-08