Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Sex chromosomes, epigenetics, and neurobehavioral disease  

Given the large sex differences in the prevalence of several neurobehavioral diseases (for example, autism is found 4 times more often in boys than in girls), this study focuses on epigenetic modification of mechanisms that underlie sex differences in behavior. This study will evaluate whether the endocrine disrupting compound, bisphenol A (BPA), can modify sex differences in behavior and, if so, whether it acts on X-chromosome genes that may be linked to diseases. Genetically engineered mice, molecular, genetic ,and behavioral methods will be used to reveal epigenetic interactions between sex chromosome genes and BPA. Specifically, the effects of sex chromosomes and BPA on juvenile social behavior in mice will be assessed, and gene expression arrays of candidate genes affected by BPA exposure during neural development will be conducted. The effects of BPA on DNA methylation and histone modification will also be examined. The goal of this research is to find genes and processes that can help diagnose, treat, and prevent mental illnesses. Project Status


Funder National Institutes of Health
Fiscal Year Funding $382,757.00
Current Award Period 2009-2012
Project Number 5R01MH086711-02
Principal Investigator Rissman, Emilie
Received ARRA Funding? No
Strategic Plan Question Question 3: What Caused This To Happen And Can This Be Prevented? (Causes)
Subcategory Epigenetics
Strategic Plan Objective New! Green dot: Objective has greater than or equal to the recommended funding. 3SK. Support two studies and a workshop that facilitate the development of vertebrate and invertebrate model systems for the exploration of environmental risks and their interaction with gender and genetic susceptibilities for ASD by 2012. IACC Recommended Budget: $1,535,000 over 3 years.
Federal or Private? Federal
Institution University of Virginia
State/Country Virginia
Web Link 1 Sex chromosomes, epigenetics, and neurobehavioral disease (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects Sex chromosomes, epigenetics, and neurobehavioral disease | $374,036.00 | 2009 | 1R01MH086711-01