Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Identification of autism genes that regulate synaptic Nrx/Nlg signaling complexes  

A key to developing therapeutic strategies to effectively treat autism spectrum disorders (ASDs) is a fundamental understanding of the cellular and molecular mechanisms that underlie them. The goal of this grant is to design an imaging-based cell screening assay in order to assess whether subsets of genes associated with ASDs lie in a common signaling pathway. By manipulating protein expression in neuronal cell cultures, researchers will use their novel screening assay to test the hypothesis that a set of the genes mutated in ASD patients function to regulate the formation of transsynaptic complexes between two key synaptic proteins, the cell adhesion molecules Neurexin and Neuroligin. Once in place, this assay can be used to identify potential drug targets to normalize cognitive function in ASD patients carrying mutations in these genes. Project Status


Funder National Institutes of Health
Fiscal Year Funding $200,000.00
Current Award Period 2010-2012
Project Number 1R21MH091471-01
Principal Investigator Garner, Craig
Received ARRA Funding? No
Strategic Plan Question Question 4: Which Treatments And Interventions Will Help? (Treatments)
Subcategory Model Systems/Therapeutic Targets
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 4SB. Standardize and validate at least 20 model systems (e.g., cellular and/or animal) that replicate features of ASD and will allow identification of specific molecular targets or neural circuits amenable to existing or new interventions by 2012. IACC Recommended Budget: $75,000,000 over 5 years.
Federal or Private? Federal
Institution Stanford University
State/Country California
Web Link 1 Identification of autism genes that regulate synaptic Nrx/Nlg signaling complexes (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
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