Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

High content screens of neuronal development for autism research  

This pilot project will develop quantitative, microscopy-based assays of neuronal development that can be used to evaluate neurons derived from lines of induced pluripotent stem cells of patients with autism and related disorders. The assay will facilitate a) the assessment of heterogeneity in neuronal development among patient populations and across individuals with autistic syndromes; b) investigation of molecular mechanisms underlying abnormal neuronal development; and c) screening of pharmaceutical compounds that may improve normal neuronal development in autism. Project Status
ONGOING

2010

Funder National Institutes of Health
Fiscal Year Funding $210,977.00
Current Award Period 2009-2011
Project Number 5R21NS070297-02
Principal Investigator Halpain, Shelley
Received ARRA Funding? Yes
Strategic Plan Question Question 4: Which Treatments And Interventions Will Help? (Treatments)
Subcategory Model Systems/Therapeutic Targets
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 4SB. Standardize and validate at least 20 model systems (e.g., cellular and/or animal) that replicate features of ASD and will allow identification of specific molecular targets or neural circuits amenable to existing or new interventions by 2012. IACC Recommended Budget: $75,000,000 over 5 years.
Federal or Private? Federal
Institution University of California, San Diego
State/Country California
Web Link 1 High content screens of neuronal development for autism research (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects High content screens of neuronal development for autism research | $207,931.00 | 2009 | 1R21NS070297-01