Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Characterization of a novel mouse model of restricted repetitive behaviors  

At the present time, there are no well- validated animal models of restricted, repetitive behaviors (RBB), a core feature of autism. The proposed studies will evaluate the C58/J inbred mouse strain as a novel animal model for the study of restricted, repetitive behaviors relevant to autism. The aims will determine whether maternal behavior contributes to the emergence of repetitive behaviors during the neonatal or post-weaning period and evaluate whether pharmacological treatment can reduce repetitive behaviors in adult C58/J mice. The final goal is to identify structural differences in the brains of C58/J mice using magnetic resonance imaging (MRI) technology. This project will positively impact the field of autism spectrum disorder research by providing information on the neurobiology of aberrant behaviors in mice and by identifying whether the C58/J inbred strain is indeed an appropriate pre-clinical screen for human RRB, as well as strengthening the emerging field of brain structural imaging in rodents. Project Status


Funder National Institutes of Health
Fiscal Year Funding $222,000.00
Current Award Period 2009-2012
Project Number 5R21MH084132-02
Principal Investigator Moy, Sheryl
Received ARRA Funding? No
Strategic Plan Question Question 4: Which Treatments And Interventions Will Help? (Treatments)
Subcategory Model Systems/Therapeutic Targets
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 4SB. Standardize and validate at least 20 model systems (e.g., cellular and/or animal) that replicate features of ASD and will allow identification of specific molecular targets or neural circuits amenable to existing or new interventions by 2012. IACC Recommended Budget: $75,000,000 over 5 years.
Federal or Private? Federal
Institution University of North Carolina at Chapel Hill
State/Country North Carolina
Web Link 1 Characterization of a novel mouse model of restricted repetitive behaviors (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects Characterization of a novel mouse model of restricted repetitive behaviors | $184,844.00 | 2009 | 1R21MH084132-01A1