Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Novel genetic animal models of autism  

Recent genetic findings have identified mutations in genes that control the formation and function of synapses in the brain as genetic causes of autism spectrum disorders (ASD). In this project, the researchers will create a novel autism mouse model by deleting a specific synaptic gene implicated in human autism patients. The mouse model will be assessed for behaviors corresponding to each of the three core symptom domains in ASD as well as for autism-relevant brain function using electrophysiology to understand effects on cortical synapses. The long-term goal of this research is to better understand a genetic cause of human autism and to use animal models of such causes to identify treatments. Project Status


Funder National Institutes of Health
Fiscal Year Funding $274,750.00
Current Award Period 2009-2011
Project Number 5R21HD065290-02
Principal Investigator Powell, Craig
Received ARRA Funding? Yes
Strategic Plan Question Question 4: Which Treatments And Interventions Will Help? (Treatments)
Subcategory Model Systems/Therapeutic Targets
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 4SB. Standardize and validate at least 20 model systems (e.g., cellular and/or animal) that replicate features of ASD and will allow identification of specific molecular targets or neural circuits amenable to existing or new interventions by 2012. IACC Recommended Budget: $75,000,000 over 5 years.
Federal or Private? Federal
Institution University of Texas Southwestern Medical Center
State/Country Texas
Web Link 1 Novel genetic animal models of autism (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects Novel genetic animal models of autism | $274,750.00 | 2009 | 1R21HD065290-01