Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Murine genetic models of autism  

This is a Clinical Investigator Award, providing a medical investigator with an opportunity to develop into an independent researcher. As such, the proposal outlines a five year program to train a child psychiatrist with research experience in human molecular genetics to study the molecular pathophysiology of autism. Recent studies implicate genetic and physical interactions of the integrin 33 and serotonin transporter genes in the determination of platelet serotonin levels as well as in autism traits. These two genes will be examined using transgenic mice to model alterations of the serotonin system in autism. Project Status


Funder National Institutes of Health
Fiscal Year Funding $172,389.00
Current Award Period 2007-2012
Project Number 5K08MH081066-04
Principal Investigator Veenstra-Vanderweele, Jeremy
Received ARRA Funding? No
Strategic Plan Question Question 4: Which Treatments And Interventions Will Help? (Treatments)
Subcategory Model Systems/Therapeutic Targets
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 4SB. Standardize and validate at least 20 model systems (e.g., cellular and/or animal) that replicate features of ASD and will allow identification of specific molecular targets or neural circuits amenable to existing or new interventions by 2012. IACC Recommended Budget: $75,000,000 over 5 years.
Federal or Private? Federal
Institution Vanderbilt University
State/Country Tennessee
Web Link 1 Murine genetic models of autism (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects Murine genetic models of autism | $172,390.00 | 2009 | 5K08MH081066-03
Murine genetic models of autism | $172,389.00 | 2008 | K08MH081066-02