Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Basal ganglia circuitry and molecules in pathogenesis of motor stereotypy  

Motor stereotypy, including repetitive movements, is a core domain of behavioral impairment in autism spectrum disorders (ASDs). This study will investigate novel basal ganglia circuitry in the brain and try to elucidate molecular mechanisms underlying the neurodevelopmental onset of motor stereotypy using a mouse genetic model. The research will establish whether selective striatonigral neuron dysfunction may be the cause of motor stereotypy and will identify candidate genes specific to the basal ganglia circuitry and molecular pathways that may underlie the motor stereotypy in this mouse model. Overall, this study may provide novel molecular and circuitry level neurobiological insights into the pathogenesis and treatment of motor stereotypy in ASDs and related neuropsychiatric disorders. Project Status


Funder National Institutes of Health
Fiscal Year Funding $387,767.00
Current Award Period 2009-2011
Project Number 5R01HD065298-02
Principal Investigator Yang, Xiangdong
Received ARRA Funding? Yes
Strategic Plan Question Question 4: Which Treatments And Interventions Will Help? (Treatments)
Subcategory Model Systems/Therapeutic Targets
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 4SB. Standardize and validate at least 20 model systems (e.g., cellular and/or animal) that replicate features of ASD and will allow identification of specific molecular targets or neural circuits amenable to existing or new interventions by 2012. IACC Recommended Budget: $75,000,000 over 5 years.
Federal or Private? Federal
Institution University of California, Los Angeles
State/Country California
Web Link 1 Basal ganglia circuitry and molecules in pathogenesis of motor stereotypy (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects Basal ganglia circuitry and molecules in pathogenesis of motor stereotypy | $419,799.00 | 2009 | 1R01HD065298-01