Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

An open resource for autism iPSCs and their derivatives  

The overall purpose of this project is to overcome a critical barrier in the field of autism research; namely, accessibility to statistically relevant numbers of patient-derived neural tissues. This novel strategy, which is based on considerable human neural stem cell (NSC), human embryonic stem cell (ESC), and biorepository experience, is to obtain fibroblasts from specific autism and control patients, derive induced pluripotent stem cells (iPSCs) from the fibroblasts, differentiate NSCs from the iPSCs, characterize and contrast and compare these cells using gene microarray and bioinformatics techniques, and provide the cells to specific autism researchers. Project Status


Funder National Institutes of Health
Fiscal Year Funding $561,413.00
Current Award Period 2009-2014
Project Number 5R01HD059967-02
Principal Investigator Schwartz, Philip
Received ARRA Funding? No
Strategic Plan Question Question 7: What Other Infrastructure and Surveillance Needs Must Be Met? (Infrastructure)
Subcategory Biobanks
Strategic Plan Objective Yellow dot: Objective has some degree of funding, but less than the recommended amount. 7D. Establish and maintain an international network of biobanks for the collection of brain, fibroblasts for pluripotent stem cells, and other tissue or biological material, by acquisition sites that use standardized protocols for phenotyping, collection, and regulated distribution of limited samples by 2011. This includes developing fibroblast repositories to produce pluripotent stem cells. Protocols should be put into place to expand the capacities of ongoing large-scale children's studies to collect and store additional biomaterials, promoting detection of biological signatures. IACC Recommended Budget for establishing biobanks by 2011: $10,500,000 over 2 years. IACC Recommended Budget for maintaining biobanks: $22,200,000 over 5 years.
Federal or Private? Federal
Institution Children's Hospital of Orange County
State/Country California
Web Link 1 An open resource for autism iPSCs and their derivatives (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects An open resource for autism iPSCs and their derivatives | $617,911.00 | 2009 | 1R01HD059967-01A2