Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Transgenic animal models for neuroscience research  

The potential associations between human genes and mental disorders are being increasingly identified, but with these associations comes a conspicuous lack of understanding of how these genes function in an afflicted, or even a presumably normal brain. By producing mice with human disease genes neuroscientists can study the behavioral, developmental, anatomical, cellular and biochemical levels of the disease. A wide range of areas of investigation have benefited from animal models produced by the Transgenic Core Facility for the NIH Intramural Research Program (IRP). One area of investigation involves autism and Phelan-McDermid syndrome. Mice are being produced in the core facility in which expression of the SHANK3 gene can be manipulated. SHANK3 is the only gene to be conclusively linked to an autism spectrum disorder. By creating animals that carry human disease genes, the complex association between genes and mental disorders can be tested directly. Project Status


Funder National Institutes of Health
Fiscal Year Funding $1,588,780.00
Current Award Period Ongoing
Project Number 1ZICMH002901-04
Principal Investigator Pickel, James
Received ARRA Funding? No
Strategic Plan Question Question 7: What Other Infrastructure and Surveillance Needs Must Be Met? (Infrastructure)
Subcategory Research Infrastructure
Strategic Plan Objective New! Green dot: Objective has greater than or equal to the recommended funding. 7P. Provide resources to centers or facilities that develop promising vertebrate and invertebrate model systems, and make these models more easily available or expand the utility of current model systems, and support new approaches to develop high-throughput screening technologies to evaluate the validity of model systems by 2013. IACC Recommended Budget: $1,100,000 over 2 years.
Federal or Private? Federal
Institution National Institutes of Health
State/Country Maryland
Web Link 1 Transgenic animal models for neuroscience research (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects N/A