Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Fraternal birth order effects on behavior  

Researchers will investigate a mouse model for the effects of older brothers on behaviors that typify autistic spectrum disorder. Preliminary evidence suggests that a mammalian mother that has carried a son to term may produce antibodies that attack the nervous system of subsequent sons in utero. By learning how older brothers increase autistic-like behaviors in mice, researchers may gain insight into the development of autism and possible therapies for this disorder.


Funder National Institutes of Health
Fiscal Year Funding $205,200.00
Project Number R21MH082273-01A1
Principal Investigator Breedlove, S. Marc
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 2.2 Support at least four research projects to identify mechanisms of metabolic and/or immune system interactions with the central nervous system that may underlie the development of ASD during prenatal-postnatal life by 2010. IACC Recommended Budget: $9,800,000 over 4 years.
Federal or Private? Federal
Institution Michigan State University
State/Country Michigan
Web Link 1 No URL available.
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects Fraternal birth order effects on behavior | $171,000.00 | 2009 | 5R21MH082273-02