Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Studies of central nervous system functional anatomy  

In clinical studies, correlations have been reported between maternal infections and higher prevalence of mental illness in their children. These researchers use the maternal immune activation (MIA) model to study disorders with early neurodevelopmental etiology, such as schizophrenia, autism, and anxiety disorder. In a set of experiments performed in rats, they have developed a MIA model in which pregnant dams are subjected to an immune challenge (LPS administration) at day 15 of gestation, and the offspring are studied for behavioral alterations (like social deficits that mirror autism and cognitive dysfunctions that mirror schizophrenia) and their underlying biochemical causes.


Funder National Institutes of Health
Fiscal Year Funding $1,048,141.00
Project Number Z01MH001090-31
Principal Investigator Herkenham, Miles
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 2.2 Support at least four research projects to identify mechanisms of metabolic and/or immune system interactions with the central nervous system that may underlie the development of ASD during prenatal-postnatal life by 2010. IACC Recommended Budget: $9,800,000 over 4 years.
Federal or Private? Federal
Institution National Institutes of Health
State/Country Maryland
Web Link 1 No URL available.
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects Studies of central nervous system functional anatomy | $1,340,580.00 | 2009 | 1ZIAMH001090-32