Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Molecular and genetic epidemiology of autism  

This research will expand and build on previous results embracing the paradigm that the wedding of new genomic technology with novel statistical methodology will bring about success. Specifically, researchers will 1) Broaden the ascertainment scheme to include the full range of the autism spectrum disorder phenotype, 2) Identify the chromosome 19 autism gene, 3) Investigate a newly defined linkage to chromosome 12 in large extended multigenerational autism families, 4) Extend studies of the GABA receptor subunits genes, 5) Identify clinically homogeneous subsets of patients and families and use the refined dataset to fine map ASD chromosomal regions and in candidate gene analyses, 6) Test for evidence of new gene/gene interactions to fully explain the spectrum of autism risk.


Funder National Institutes of Health
Fiscal Year Funding $1,166,487.00
Project Number R01MH080647-12
Principal Investigator Pericak-Vance, Margaret
Strategic Plan Question Question 3: What Caused This To Happen And Can This Be Prevented? (Risk Factors)
Strategic Plan Objective Yellow dot: Objective has some degree of funding, but less than the recommended amount. 3.2 Coordinate and implement the inclusion of approximately 20,000 subjects for genome-wide association studies, as well as a sample of 1,200 for sequencing studies to examine more than 50 candidate genes by 2011. IACC Recommended Budget: $43,700,000 over 4 years.
Federal or Private? Federal
Institution University of Miami Miller School of Medicine
State/Country Florida
Web Link 1 No URL available.
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects Molecular and genetic epidemiology of autism | $1,211,372.00 | 2009 | 5R01MH080647-13
Molecular and genetic epidemiology of autism | $1,186,466.00 | 2010 | 5R01MH080647-14